abstract：OBJECTIVE:To describe the advantages, disadvantages, practical considerations, and future developments of transcutaneous drug delivery. MATERIALS AND METHODS:The physiochemical properties of the drug preparation that are factors in the effectiveness of transcutaneous transport are drug stability or volatility, use of ...

journal_title：Mayo Clinic proceedings

authors： Berti JJ,Lipsky JJ

更新日期：1995-06-01 00:00:00

abstract：OBJECTIVE:To determine the clinical characteristics of hospitalized patients who died of pulmonary embolism, confirmed by evaluative autopsy. DESIGN:We retrospectively analyzed a series of autopsy cases of pulmonary embolism at a tertiary-care center for the period Jan. 1, 1985, through Dec. 31, 1989. MATERIAL AND ME...

journal_title：Mayo Clinic proceedings

authors： Morgenthaler TI,Ryu JH

更新日期：1995-05-01 00:00:00

abstract：OBJECTIVE:To report the clinical responses and mediator-release profiles of an aspirin-sensitive man with systemic mast cell disease during aspirin desensitization. MATERIAL AND METHODS:We quantified the release of six mediators during aspirin desensitization. RESULTS:Although aspirin was administered cautiously with...

journal_title：Mayo Clinic proceedings

authors： Butterfield JH,Kao PC,Klee GC,Yocum MW

更新日期：1995-05-01 00:00:00

abstract：OBJECTIVE:To characterize the findings associated with acute febrile neutrophilic dermatosis (Sweet's syndrome [SS]) and the response of SS to treatment. DESIGN:We retrospectively reviewed 48 cases of SS encountered at the Mayo Clinic between 1980 and 1992. MATERIAL AND METHODS:Histopathologic specimens and medical r...

journal_title：Mayo Clinic proceedings

authors： Fett DL,Gibson LE,Su WP

更新日期：1995-03-01 00:00:00

abstract：:The increased frequency of prenatal ultrasonography has resulted in an increase in the detection of fetal genitourinary abnormalities, many of which are of minimal clinical significance. Severe fetal urinary tract obstruction with associated oligohydramnios results in a recognizable constellation of physical findings,...

journal_title：Mayo Clinic proceedings

authors： Gloor JM

更新日期：1995-02-01 00:00:00

abstract：:The frequently encountered disorder of venous thromboembolism (VTE) can cause serious morbidity and even death. Nevertheless, in more than 70% of patients who die of pulmonary embolism (PE), the diagnosis is not considered before death. Thus, clinicians should have a high index of suspicion for VTE, especially in high...

journal_title：Mayo Clinic proceedings

authors： Rosenow EC 3rd

更新日期：1995-01-01 00:00:00

abstract：OBJECTIVE:To present the epidemiologic and clinical features of renovascular disease and discuss various diagnostic approaches. DESIGN:We describe the findings in patients with fibromuscular dysplasia or atherosclerotic disease of the renal arteries and review pertinent studies from the literature. RESULTS:Renovascul...

journal_title：Mayo Clinic proceedings

authors： Canzanello VJ,Textor SC

更新日期：1994-12-01 00:00:00

abstract：OBJECTIVE:To describe current concepts in the diagnosis and treatment of brain metastases. RESULTS:More than 25% of all autopsy-proven brain metastases have a pulmonary source. Most brain metastases manifest with a combination of focal and generalized symptoms and signs. Typically, patients have subacute, progressive ...

journal_title：Mayo Clinic proceedings

authors： O'Neill BP,Buckner JC,Coffey RJ,Dinapoli RP,Shaw EG

更新日期：1994-11-01 00:00:00

abstract：OBJECTIVE:To examine current therapeutic modalities for acute lymphocytic leukemia (ALL) in adults, analyze prognostic variables, and offer treatment recommendations. DESIGN:We reviewed our experience with 90 adult patients with ALL examined at the Mayo Clinic between 1982 and 1992 and used it as a background for disc...

journal_title：Mayo Clinic proceedings

authors： Ho TC,Tefferi A,Su JQ,Litzow MR,Hoagland HC,Noël P

更新日期：1994-10-01 00:00:00

abstract：OBJECTIVE:To review recent advances in the diagnosis and treatment of gastroesophageal reflux disease (GERD). MATERIAL AND METHODS:Original English language reports were obtained through a Medline search of the National Library of Medicine up to and including 1993. The reference lists of all original reports and revie...

journal_title：Mayo Clinic proceedings

authors： DeVault KR,Castell DO

更新日期：1994-09-01 00:00:00

abstract：:Dyspnea is a common symptom that is difficult to define and can result from a wide variety of causes. This complex sensation that arises from multiple stimuli involves both subjective perceptions and objective reactions. In the assessment of patients with dyspnea, use of a systematic approach to determine the precipit...

journal_title：Mayo Clinic proceedings

authors： Gillespie DJ,Staats BA

更新日期：1994-07-01 00:00:00

abstract：OBJECTIVE:To record long-term follow-up data on patients with chronic idiopathic meningitis. DESIGN:We retrospectively reviewed the outcome of 49 patients who were examined at the Mayo Clinic between 1978 and 1990. MATERIAL AND METHODS:For all patients, symptoms, signs, laboratory values, results of imaging studies, ...

journal_title：Mayo Clinic proceedings

authors： Smith JE,Aksamit AJ Jr

更新日期：1994-06-01 00:00:00

abstract：OBJECTIVE:To assess the predictive value of a series of demographic and clinical variables for stroke and survival in a population after a first transient ischemic attack (TIA). DESIGN:Cox proportional hazards regression analysis was used to determine the association of various demographic and clinical factors with su...

journal_title：Mayo Clinic proceedings

authors： Evans BA,Sicks JD,Whisnant JP

更新日期：1994-05-01 00:00:00

abstract：:A 27-year-old man was treated for an aggressive cerebellar medulloblastoma that, at operation, exhibited dural invasion. Six months after gross total resection and radiation therapy, a "surgical metastasis" developed in the lower portion of the surgical scar. The tumor grew rapidly down into the right side of his neck...

journal_title：Mayo Clinic proceedings

authors： Tomlinson FH,Jenkins RB,Scheithauer BW,Keelan PA,Ritland S,Parisi JE,Cunningham J,Olsen KD

更新日期：1994-04-01 00:00:00

abstract：OBJECTIVE:To determine whether pancreas transplantation alters lipid and lipoprotein concentrations and whether peripheral hyperinsulinemia is always associated with altered lipid levels. DESIGN:We assessed the lipid profiles of seven pancreas-kidney recipients with insulin-dependent diabetes mellitus, seven kidney re...

journal_title：Mayo Clinic proceedings

authors： Katz HH,Nguyen TT,Velosa JA,Robertson RP,Rizza RA

更新日期：1994-03-01 00:00:00

abstract：OBJECTIVE:To report the third known and documented occurrence of malignant disease as a complication of immunosuppression associated with low-dose methotrexate therapy for rheumatoid arthritis. MATERIAL AND METHODS:We present a case report of a 64-year-old woman with rheumatoid arthritis who had received low-dose meth...

journal_title：Mayo Clinic proceedings

authors： Zimmer-Galler I,Lie JT

更新日期：1994-03-01 00:00:00

abstract：OBJECTIVE:The current study was undertaken to assess the frequency of excessive enteric protein loss and protein-losing enteropathy in the relatively early period after the Fontan operation. DESIGN:Protein excretion was determined in 26 of 27 consecutive patients who underwent the Fontan procedure between January and ...

journal_title：Mayo Clinic proceedings

authors： Davis CA,Driscoll DJ,Perrault J,Greenwood DH,Schaff HV,Puga FJ,Danielson GK,Feldt RH

更新日期：1994-02-01 00:00:00

abstract：OBJECTIVE:In this report, our goal was to summarize the current knowledge of the biochemical basis for the impaired DNA synthesis and neuropathy associated with vitamin B12 deficiency. MATERIAL AND METHODS:We reviewed the pertinent literature and our clinical experience with cobalamin deficiency. RESULTS:Studies have...

journal_title：Mayo Clinic proceedings

authors： Tefferi A,Pruthi RK

更新日期：1994-02-01 00:00:00

abstract：FINDINGS:The prostate-specific antigen (PSA) level alone does not facilitate precise pathologic staging on an individual basis, although advanced stage tends to correlate with an increased PSA level. The staging accuracy of PSA, however, can be enhanced by considering the variables of tumor grade and clinical stage. St...

journal_title：Mayo Clinic proceedings

authors： Ruckle HC,Klee GG,Oesterling JE

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:The efficacy of fine-needle aspiration (FNA) biopsy and its role in the management of a nodular goiter are clearly established. The accuracy of cytologic diagnosis approaches 95%. FINDINGS:FNA biopsy is a reasonable approach to thyroid nodules; it has decreased costs substantially because it facilitates sel...

journal_title：Mayo Clinic proceedings

authors： Gharib H

更新日期：1994-01-01 00:00:00

abstract：DESIGN:A quality-control retrospective review of medical records was conducted for cases of anaphylaxis encountered at Mayo Clinic Rochester during a 3 1/2-year period. PATIENTS:For inclusion in the study, all patients had to manifest general symptoms of mediator release such as generalized pruritus, urticaria, angioe...

journal_title：Mayo Clinic proceedings

authors： Yocum MW,Khan DA

更新日期：1994-01-01 00:00:00

abstract：:The ventriculoatrial shunt (VAS) was developed to control hydrocephalic syndromes effectively. Several complications, however, have been described after the procedure. One of the most serious consequences is the development of severe pulmonary hypertension attributed to multiple and recurrent pulmonary embolization ca...

journal_title：Mayo Clinic proceedings

authors： Pascual JM,Prakash UB

更新日期：1993-12-01 00:00:00

abstract：:We used a laparoscopic technique for the percutaneous placement of the peritoneal end of cerebrospinal fluid shunts in adult patients with obstructive or normal-pressure hydrocephalus. Concurrent with the initial cranial part of the procedure, pneumoperitoneum is established in a routine fashion, and a video-laparosco...

journal_title：Mayo Clinic proceedings

authors： Schievink WI,Wharen RE Jr,Reimer R,Pettit PD,Seiler JC,Shine TS

更新日期：1993-11-01 00:00:00

abstract：:Ocular adnexal lymphoproliferative lesions consist of a spectrum of disease entities, including reactive lymphoid hyperplasia, atypical lymphoid hyperplasia, and lymphoma. No clinical or radiologic criteria facilitate a distinction among these lymphoproliferative lesions. The two hyperplastic processes may evolve to l...

journal_title：Mayo Clinic proceedings

authors： Liesegang TJ

更新日期：1993-10-01 00:00:00

abstract：:The aim of this study was to determine whether the characteristics of esophageal symptoms may be of diagnostic utility in distinguishing dysphagia of various causes. Included in the study were a total of 499 patients with three types of dysphagia: 234 with dysphagia related to an obstructive lesion in the esophagus, 1...

journal_title：Mayo Clinic proceedings

authors： Kim CH,Weaver AL,Hsu JJ,Rainwater L,Zinsmeister AR

更新日期：1993-10-01 00:00:00

abstract：:Primary sclerosing cholangitis (PSC) predisposes to the development of cholangiocarcinoma, a usually fatal complication that is difficult to diagnose. Serum concentrations of CA 19-9, a tumor-associated antigen, are frequently increased in patients with only cholangiocarcinoma. The aim of this study was to assess the ...

journal_title：Mayo Clinic proceedings

authors： Nichols JC,Gores GJ,LaRusso NF,Wiesner RH,Nagorney DM,Ritts RE Jr

更新日期：1993-09-01 00:00:00

abstract：:Humanism and the humanities open the way to communication, to a better professional and political performance, and to a better image of the profession in the eyes of its "real" public. They also offer to individual physicians a richer life, a greater understanding of their own achievements, a protection against isolat...

journal_title：Mayo Clinic proceedings

authors： Little JM

更新日期：1993-09-01 00:00:00

abstract：:Benign prostatic hyperplasia (BPH), a nonmalignant neoplasm of the prostatic epithelial and stromal tissue, occurs commonly in elderly men. The "gold standard" of care for symptomatic BPH has been and remains transurethral resection of the prostate. This operation, however, like any surgical procedure, has associated ...

journal_title：Mayo Clinic proceedings

authors： Monda JM,Oesterling JE

更新日期：1993-07-01 00:00:00

abstract：:From January 1975 through July 1987 at the Mayo Clinic, 16 patients received postoperative adjuvant radiation therapy for squamous cell carcinoma of the tonsil (pathologic stage I in 4 patients, stage III in 3, and stage IV in 9). Follow-up was continued for a minimum of 2 years or until death. At 5 years, overall sur...

journal_title：Mayo Clinic proceedings

authors： Thompson WM,Foote RL,Olsen KD,Schaid DJ,Grado GL,Buskirk SJ,Earle JD

更新日期：1993-07-01 00:00:00

abstract：:We describe three critically ill patients who displayed indirect evidence of transient corticotropin deficiency. All these patients were elderly, were poorly nourished, and had unexplained hypotension intraoperatively or immediately postoperatively. During the hypotensive episodes, they had inappropriately low plasma ...

journal_title：Mayo Clinic proceedings

authors： Kidess AI,Caplan RH,Reynertson RH,Wickus GG,Goodnough DE

更新日期：1993-05-01 00:00:00

abstract：:Emergency teams asked to provide cardiopulmonary resuscitation for pediatric patients often consist of nurses and physicians from various pediatric and nonpediatric specialties. Team members should agree on the timing of termination of unsuccessful resuscitative efforts; however, no firm guidelines about such timing h...

journal_title：Mayo Clinic proceedings

authors： O'Marcaigh AS,Koenig WJ,Rosekrans JA,Berseth CL

更新日期：1993-04-01 00:00:00

abstract：:Evidence that host immunologic function may influence the behavior of lung cancer is accumulating. Non-small-cell lung cancers are heavily infiltrated by host lymphocytes. The fact that monoclonal antibodies have been developed against lung cancer cells implies that such cells express surface antigens and are therefor...

journal_title：Mayo Clinic proceedings

authors： Pisani RJ

更新日期：1993-04-01 00:00:00

abstract：:A 71-year-old man had painful blue toes after an episode of protracted vomiting. Abdominal, cardiac, and transesophageal ultrasound studies were performed before angiography was considered. A large mobile mass in the proximal descending thoracic aorta, which suggested thrombus, was identified by transesophageal echoca...

journal_title：Mayo Clinic proceedings

authors： Blackshear JL,Jahangir A,Oldenburg WA,Safford RE

更新日期：1993-03-01 00:00:00

abstract：:Between January 1973 and October 1991 at the Mayo Clinic, 5 of 345 patients with Wegener's granulomatosis initially had features suggestive of giant cell arteritis and subsequently were found to have biopsy-proven vasculitis of the temporal artery. All five patients were older than 60 years of age and had jaw claudica...

journal_title：Mayo Clinic proceedings

authors： Nishino H,DeRemee RA,Rubino FA,Parisi JE

更新日期：1993-02-01 00:00:00

abstract：:In order to test the safety of hot tub use for persons with heart disease, 15 men with clinically stable coronary artery disease underwent 15 minutes of immersion in a hot tube at 40 degrees C. On another day, they exercised on a cycle ergometer for 15 minutes; target heart rate was determined by standard methods. Tym...

journal_title：Mayo Clinic proceedings

authors： Allison TG,Miller TD,Squires RW,Gau GT

更新日期：1993-01-01 00:00:00

abstract：:In recent cases on the constitutionality of sentencing to death criminals who were younger than 18 years of age at the time of their crimes or who are mentally retarded, the US Supreme Court has rejected medical evidence that such persons categorically possess diminished culpability. Rather, the Court has accepted the...

journal_title：Mayo Clinic proceedings

authors： Helminski F

更新日期：1993-01-01 00:00:00

abstract：:Between Jan. 1, 1976, and Dec. 31, 1985, at our institution, 37 patients who had undergone prior complete surgical resection of non-small-cell lung cancer received definitive thoracic radiation therapy (TRT) for locally recurrent disease. Of the 37 recurrences, 33 were in the pulmonary parenchyma or the hilar, mediast...

journal_title：Mayo Clinic proceedings

authors： Shaw EG,Brindle JS,Creagan ET,Foote RL,Trastek VF,Buskirk SJ

更新日期：1992-12-01 00:00:00

abstract：:To our knowledge, edema of the lower extremities has not previously been reported as a sign of a pancreatic pseudocyst. In this case report, we describe a 66-year-old man in whom such a lesion compressed the inferior vena cava and caused pronounced leg swelling. After drainage of the pseudocyst, the edema did not recu...

journal_title：Mayo Clinic proceedings

authors： Browman MW,Litin SC,Binkovitz LA,Mohr DN

更新日期：1992-11-01 00:00:00

abstract：:The extent of universal screening for gestational diabetes and the incidence of gestational diabetes mellitus (GDM) by diagnosis were analyzed in four primary-care sites. The medical records of 798 women were reviewed to identify the presence of historical risk factors, familial determinants, and biophysical attribute...

journal_title：Mayo Clinic proceedings

authors： Mazze RS,Krogh CL

更新日期：1992-10-01 00:00:00

abstract：:We reviewed the epidemiologic characteristics, diagnosis, clinical features, and management of cytomegalovirus (CMV) infection after renal transplantation. CMV, the major viral pathogen after renal transplantation, increases patient morbidity and mortality. The spectrum of CMV infection ranges from latent infection to...

journal_title：Mayo Clinic proceedings

authors： Farrugia E,Schwab TR

更新日期：1992-09-01 00:00:00